Molecular Targeting in Oncology

von: Howard L. Kaufman, Scott Wadler, Karen Antman

Humana Press, 2007

ISBN: 9781597453370 , 728 Seiten

Format: PDF, OL

Kopierschutz: Wasserzeichen

Windows PC,Mac OSX Apple iPad, Android Tablet PC's Online-Lesen für: Windows PC,Mac OSX,Linux

Preis: 248,71 EUR

Mehr zum Inhalt

Molecular Targeting in Oncology


 

Introduction

7

Contents

9

Contributors

12

I General Strategies for Molecular Targeting in Oncology

16

The Cell Cycle

17

mTOR

47

Ras/Raf/MEK Inhibitors

68

17-AAG

87

The Cancer Epigenome

108

II Molecular Targeting for Specific Disease Sites

125

Molecular Targeting in Upper Gastrointestinal Malignancies

126

Molecular Targeting of Colorectal Cancer

141

Molecular Targeting in Hepatocellular Carcinoma

172

Molecularly Targeted Therapy in Pancreatic Cancer

218

Untargeted Use of Targeted Therapy

234

Renal Cell Carcinoma

248

Targeted Therapies for Prostate Cancer

269

Molecular Targets in Ovarian Cancer and Endometrial Cancer

297

Targeted Therapy For Breast Cancer

315

Melanoma

349

III Classes of Drugs for Molecular Targeting in Oncology

374

Antibody Therapy of Cancer

375

Nucleic Acid Therapies for Cancer Treatment

417

Engineering Oncolytic Measles Viruses for Targeted Cancer Therapy

434

Vaccines as Targeted Cancer Therapy

449

Cytokine-Based Therapy for Cancer

472

Cyclooxygenase-2 as a Target for Cancer Prevention and Treatment

509

IV Specific Drugs for Molecular Targeting in Oncology

542

Imatinib Mesylate (Gleevec and the Emergence of Chemotherapeutic Drug- Resistant Mutations

543

Development of a Targeted Treatment for Cancer

556

VEGF Inhibition for Cancer Therapy

569

Somatostatin Analogue Therapy

581

V Challenges in Molecular Targeting in Oncology

634

Patient Selection for Rational Development of Novel Anticancer Agents

635

Clinical Trial Design with Targeted Agents

643

How to Define Treatment Success or Failure if Tumors Do Not Shrink

650

Molecular Imaging in Oncology

668

Combinations of Molecular- Targeted Therapies

685

Preclinical Development of Molecularly Targeted Agents in Oncology

698

Index

714